Lymphatic & Immune / VISUAL EXPLAINER

How Can White Blood Cells Leave a Blood Vessel?

A common leukocyte recruitment sequence includes rolling, firm adhesion and passage across the vessel wall. This example shows a neutrophil-like cell crossing between endothelial cells, not blood simply leaking out; routes and recruitment steps vary with tissue and cell type.

Three panels show a lobulated white cell rolling, flattening on endothelium and elongating between neighboring cells toward tissue below; red cells remain in the lumen above.
English illustration · P0152 · Version 1.0

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What the illustration shows

English poster titled How White Cells Leave the Blood. Three stacked tissue panels show a pale granular white cell with a connected lobulated purple nucleus: rolling along the luminal surface, flattening during firm adhesion, then elongating between two neighboring endothelial cells toward the tissue below. Red cells remain in the blood lumen above the wall. Labels distinguish Blood lumen, Endothelium and Tissue side. A downward arrow indicates crossing. A lower inset compares rounded and elongated cell shapes. The caveat says One illustrated route across a small-vessel wall; Simplified sequence; Not to scale; Routes vary. Gold AllHumanBody.com and full slogan finish the poster.

How to interpret this poster

AI-assisted educational illustration, adapted into web-sized images without changing its composition. This is general education, not an individual diagnosis or treatment recommendation.

EVIDENCE / CONTEXT

Sources and what they support

  1. Anatomy and Physiology 2e: 18.4 Leukocytes and Platelets ↗

    Small-vessel exit between adjacent endothelial cells and tissue chemical guidance; preserved direct lines 35–39 and fresh reread.

  2. Organ-Specific Mechanisms of Transendothelial Neutrophil Migration in the Lung, Liver, Kidney, and Aorta ↗

    Rolling, stable adhesion and subsequent transmigration as a model-dependent cascade with organ-specific variation.

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How Can White Blood Cells Leave a Blood Vessel?

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